[Answer] Which choice best describes the purpose of most pharmacogenomic research?

Which choice best describes the purpose of most pharmacogenomic research

Question: Which choice best describes the purpose of most pharmacogenomic research?

Answer: To evaluate the association between individual genotypes and the safety and efficacy of a particular drug or class of drugs.

Explanation

The primary purpose of pharmacogenomic research is to evaluate the association between individual genotypes and the safety and efficacy of a particular drug or class of drugs.

This information can help to guide the safe and effective use of medications for individual patients.

Pharmacogenomic research may also be used to identify new biomarkers that can be used to assess a patient’s risk of adverse drug reactions or to determine their optimal drug dosage.

What is Pharmacogenomics ?

Pharmacogenomics is the study of how an individual’s genes affect their response to medications.

Pharmacogenomic testing uses an individual’s genetic information to predict their response to specific medications and dosage levels. Such tests may also identify individuals who are at risk for developing adverse drug reactions.

Pharmacogenomics deals with the role of genomic differences in drug response among patients. It is a science that studies how a person’s genetic makeup affects their response to a medication.

Pharmacogenomics is the study of how an individual’s genes affect their response to medications. Pharmacogenomic testing uses an individual’s genetic information to predict their response to specific medications and dosage levels.

Such tests may also identify individuals who are at risk for developing adverse drug reactions.

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How is pharmacogenomic testing done?

1. A blood sample is taken from the individual to be tested and sent off for analysis

2. The genetic markers that are relevant to how a given drug impacts an individuals risk of side effects are examined in detail

3. The pharma company sends the test back with lab-reported results which take into account both their specific genetic predisposition as well as doctor-suggested preferences on a treatment plan, a doctor will then discuss with you, or your parents or caregiver any additional risks associated with this medication

4. This information may impact the treatment plan by changing doses, selection of medications, and avoidance of repeat prescriptions with identified problem drugs

5. Pharmacogenomic testing can identify people who might have difficulty metabolizing:

a) Warfarin leading to poor anticoagulation and bleeding

b) Theophylline causing seizures and cardiac arrhythmias

c) Drugs metabolized by CYP2D6 causing QT prolongation leading to Torsade de Pointes (TdP) or Serotonin Syndrome (SS)

d) Antidepressants metabolized by CYP2D6 leading to SS or seizures

e) Digoxin, Carbamazepine, Phenytoin, Diazepam, and other GABAergic-acting drugs lead to sedation, respiratory depression, or even coma

f) Tricyclic antidepressants (TCAs), SSRIs, Venlafaxine, Desvenlafaxine, Duloxetine metabolized by CYP2D6 leading to SS or seizures

g) Fluoxetine metabolism by CYP2C19 leading to QT prolongation and TdP

h) Omeprazole metabolism by CYP2C19 leading to decreased drug levels and therapeutic failure

i) Irinotecan (Camptosar) metabolism by UGT1A1 leading to severe neutropenia

Potential Benefits of Pharmacogenomics

The potential benefits of pharmacogenomics are many. By understanding how a person’s genes affect their response to medications, pharmacogenomic testing can help to improve drug safety and efficacy.

It can also help to reduce the cost of healthcare by minimizing the need for expensive and potentially harmful drug trials.

Pharmacogenomics may also play a role in personalized medicine, which is an emerging field that aims to tailor medical treatments to individual patients based on their genetic information.

To evaluate the potential for a drug or class of drugs to cause adverse drug reactions in individual patients

In this context, “pharmacogenomic testing” refers to DNA-based tests that use an individual’s genetic information to predict their response to specific medications and dosage levels. Such tests may also identify individuals who are at risk for developing adverse drug reactions.

While pharmacogenomic tests are currently available, the field of pharmacogenomics is still in its infancy and very few (if any) pharmacogenomic tests have been approved by regulatory agencies like the U.S. Food and Drug Administration (FDA).

Currently, available pharmacogenomics tests may not be appropriate for use in clinical decision-making. However, some FDA-approved pharmacogenomic tests are already being used to guide the safe and effective use of medications for individual patients.

To identify new biomarkers that can be used to assess a patient’s risk of adverse drug reactions or to determine their optimal drug dosage

A common goal in pharmacogenomics is to identify new biomarkers that can be used to assess a patient’s risk of adverse drug reactions or to determine their optimal drug dosage. Such biomarkers could help to improve the safe and effective use of medications for individual patients.

Pharmacogenomic research may also lead to the development of personalized medicine, which is an emerging field that aims to tailor medical treatments to individual patients based on their genetic information.

To explore the association between individual genotypes and the safety and efficacy of a particular drug or class of drugs

Pharmacogenomics is the study of how an individual’s genes affect their response to medications. Pharmacogenomic testing uses an individual’s genetic information to predict their response to specific medications and dosage levels.

Such tests may also identify individuals who are at risk for developing adverse drug reactions.

To evaluate the potential risks associated with administering a specific medication to an individual patient

Pharmacogenomics is the study of how an individual’s genes affect their response to medications. Pharmacogenomic testing uses an individual’s genetic information to predict their response to specific medications and dosage levels. Such tests may also identify individuals who are at risk for developing adverse drug reactions.

Pharmacogenomics FAQ

Final Words

Pharmacogenomic research is used to help identify how a person’s genes can affect their response to drugs. This information can be used to develop better medication therapies and to predict which medications will be most effective for a person.

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